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KMID : 1134820150440040635
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Journal of the Korean Society of Food Science and Nutrition
2015 Volume.44 No. 4 p.635 ~ p.640
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Antioxidative and Antiproliferative Effects of Lindera glauca Blume on Human Colorectal Cancer Cells
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Kim Yeah-Un
Yun Jung-Mi
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Abstract
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Various medicinal plants were collected, air-dried, and subjected to extraction with ethanol. Ethanol extracts were screened for their efficacies as antioxidative and antiproliferative agents against cancer cells. Among the 15 species, extract of Lindera glauca Blume stem with a total polyphenolic content of 70.99±1.88 μg/TAE μg, was found to possess high DPPH radical scavenging (IC50=30.54±0.62 μg/mL), nitrite scavenging (IC50=787.94±89.28 μg/mL), and reducing power activities (595.76±1.90 μg/mL). The antiproliferative activities of plant extracts were determined using MTT assay in human colorectal cancer cells. Extracts of stems and roots from L. glauca Blume were found to possess high anti-proliferative activities in HT-29 and HCT116 cells (IC50=711.52±40.27 μg/mL and IC50=85.07±4.06 μg/mL, respectively). These results suggest that L. glauca Blume extract could be a useful natural antioxidant and anticancer resource.
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KEYWORD
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antioxidant, antiproliferative, Lindera glauca Blume, colon cancer
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